Associations of Polymorphic Variants of CCK, CCKAR, and CCKBR Genes with Panic Disorder

Panic disorder is a widespread socially significant disease which genetic nature is poorly known. Since panic-driving features of cholecystokinin had been discovered, the gene that encodes this polypeptide (CCK ) and its receptors (CCKAR, CCKBR), as well as the mutations within, have been extensively studied. The aim of the present research was to assess frequencies of occurrence of seven single nucleotide substitutions in genes CCK, CCKAR, and CCKBR in the sample of patients with diagnosed panic disorder, and in the control sample of unexamined Moscow citizens. Reliable increase in occurrence frequency of rs1805000:T single nucleotide substitution in CCKBR gene was eventually found in the sample of panic disorder patients compared to the control, which allow us to suspect the involvement of this SNP into panic disorder aetiology. We also found the association of allele combination CCK rs11571842:A + CCKAR rs1800908:T with panic disorder development.