The effect of sodium chondroitin sulfate on free-radical processes in cartilage tissue of rats with osteoarthrosis

It was established, that at osteoarthrosis, induced by the administration of monoiodine acetate, the oxide stress develops in the cartilage tissue of knee joints, at that the content of active forms of oxygen and products of lipids peroxide oxidation grows, especially: hydrogen peroxide, superoxide-anion radical, dienoic conjugates, RBA-active products and Schiff bases. Activities of xantinoxidase prooxidant enzyme and antioxidant superoxidysmutase also grew at the pathology. It was revealed, that at administering the preparation on the base of chondroitin sulfate, the content of active forms of oxygen and products of lipids peroxide oxidation decreased in the cartilage tissue of rats with chemically induced osteoarthrosis. The negative control proved that the preparation on the base of chondroitin sulfate doesn't influence the shift of the prooxidant-antioxidant balance in experimental animals. The obtained data testify to antioxidant properties of this preparation