Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

Suk Youl Park,Jung-Eun Park,Tae Sung Kim,Ju Hee Kim,Mi Jeong Kwak,Bonsu Ku,Lan Tian,Ravichandran N. Murugan,Mija Ahn,Shinobu Komiya,Hironobu Hojo,Nam Kim,Bo Yeon Kim,Jeong K. Bang,Raymond L. Erikson,Ki Won Lee,Seung Jun Kim,Byung-Ha Oh,Wei Yang,Kyung S. Lee

Molecular basis for unidirectional scaffold switching of human Plk4 in centriole biogenesis

2014

Plk4 regulates centriole duplication. Two centrosomal scaffold proteins, Cep192 and Cep152, are shown to interact with Plk4 in a temporally and spatially regulated manner, and structural analyses reveal that these interactions are mutually exclusive.

Keywords:

Scaffold protein
PLK4
Centriole
Plasma protein binding
Cell Cycle Protein
Cell biology
Biogenesis
Scaffold
Centrosome cycle
Biology

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