Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions.
2007
The aim of the present work was to study the effect of various
stressors (hypoxia, cold, immobilization) on the gene
expression of sigma receptors in the left ventricles of rat
heart. We have clearly shown that gene expression of sigma
receptors is upregulated by strong stress stimuli, such as
immobilization and/or hypoxia. Nevertheless, cold as a milder
stressor has no effect on sigma receptors mRNA levels.
Signalling cascade of sigma receptors is dependent on IP3
receptors, since silencing of both, type 1 and 2 IP3 receptors
resulted in decreased mRNA levels of sigma receptors.
Physiological relevance of sigma receptors in the heart is not
clear yet. Nevertheless, based on the already published data we
can assume that sigma receptors might participate in
contractile responses in cardiomyocytes.
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