CYP2C19 genotyping and associated mephenytoin hydroxylation polymorphism in a Canadian Inuit population.

The CYP2C19-associated oxidation polymorphism of mephenytoin was investigated in an Inuit population living in the high Arctic of Canada. Results were obtained for 152 subjects, of whom 90 were unrelated to first degree relatives. Phenotyping was based on the capillary gas chromatographic determinat