The m 6 A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca 2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway

Background Previous study demonstrated that extracellular ATP could promote cell migration and invasion in multiple human cancers. Till now, the pro-invasive mechanisms of ATP and P2RX6, a preferred receptor for ATP, are still poorly studied in RCC.