New mycotoxins from Fusarium sambucinum

Isolation, characterization, and bioassay results of three new trichothecene mycotoxins, 3-ketoapotrichothecene, FS-3, and FS-4, as well as a new bisaboline, 4,5,10,11-tetrahydroxybisaboline, from Fusarium sambucinum are presented. 3,15-Diacetoxyscirpenol (3,15-DAS), FS-1, and 3α- and 3β-hydroxyapotrichothecenes are reported for the first time from F. sambucinum. The previously reported 4,15-diacetoxyscirpenol (4,15-DAS) (anguidine), 4-monoacetoxyscirpenol (4-MAS), 15-MAS, 3,4,15-triacetoxyscirpenol (TAS), neosolaniol, sambucoin, and scirpenetriol were also found. The solid-state structure of DAS (anguidine) obained from single-crystal X-ray analysis is reported