A new synthesis of N-substituted о-trifluoroacetylanilines

Abstract A method for the synthesis of N-substituted о -trifluoroacetylanilines by the reaction of N-substituted isatoic anhydrides with (trifluoromethyl)trimethylsilane (Ruppert–Prakash reagent) has been developed. This method provides easy access to both N-alkyl- о -trifluoroacetylanilines and N-aryl- о -trifluoroacetylanilines in high yields. Cyclisation of N-aryl- о -trifluoroacetylanilines in trifluoroacetic acid gives 9-trifluoromethylacridines.