Four New Acetogenins from the Seeds of Annona reticulata 1

Abstract Four new acetogenins, dieporeticanin-1 and -2 (1 and 2 respectively), dieporeticenin (3) and trieporeticanin (4) were isolated, with the known diepomuricanin (5), from the seeds of the vietnamese Annonaceae, Annona reticulata. Their structures were elucidated on the basis of the spectral data. Biomimetic hemi-synthesis of reticulatacin (6), solamin (7) from dieporeticanin-1 (1), diepomuricanin (5) respectively, sustains the key role of such natural precursors in the biogenesis of acetogenins.