Visualization and targeting of LGR5 + human colon cancer stem cells

Mariko Shimokawa,Yuki Ohta,Shingo Nishikori,Mami Matano,Ai Takano,Masayuki Fujii,Shoichi Date,Shinya Sugimoto,Takanori Kanai,Toshiro Sato

Visualization and targeting of LGR5 + human colon cancer stem cells

2017

Mariko Shimokawa
Yuki Ohta
Shingo Nishikori
Mami Matano
Ai Takano
Masayuki Fujii
Shoichi Date
Shinya Sugimoto
Takanori Kanai
Toshiro Sato

LGR5+ cells in human colorectal cancer tissue xenografted into mice act as cancer stem cells, and differentiated cancer cells can revert to cancer stem cells and express LGR5 after ablation of existing LGR5+ cells.

Keywords:

Somatic evolution in cancer
CA15-3
Cancer cell
CA19-9
Stem cell
Adoptive cell transfer
Cancer research
Cancer stem cell
Biology
Mouse model of colorectal and intestinal cancer
Cancer
Cellular differentiation
LGR5

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