An Ontology-Based Artificial Intelligence Model for Medicine Side-Effect Prediction: Taking Traditional Chinese Medicine as An Example.

In this work, an ontology-based model for AI-assisted medicine side-effect (SE) prediction is developed, where three main components, including the drug model, the treatment model, and the AI-assisted prediction model, of proposed model are presented. To validate the proposed model, an ANN structure is established and trained by two hundred and forty-two TCM prescriptions that are gathered and classified from the most famous ancient TCM book and more than one thousand SE reports, in which two ontology-based attributions, hot and cold, are simply introduced to evaluate whether the prediction will cause a SE or not. The results preliminarily reveal that it is a relationship between the ontology-based attributions and the corresponding indicator that can be learnt by AI for predicting the SE, which suggests the proposed model has a potential in AI-assisted SE prediction. However, it should be noted that, the proposed model highly depends on the sufficient clinic data, and hereby, much deeper exploration is important for enhancing the accuracy of the prediction.