Synthesis of the N-Substituted Pyridin-1(2H)-one Framework by Ligand-Assisted Pd-Catalyzed Reactions

An efficient Pd-catalyzed method for the synthesis of N-substituted pyridin-1(2H)-ones was developed. The corresponding derivatives, which can be found in numerous biologically active compounds, were obtained in good to excellent yields. A possible mechanism for this reaction is discussed.