An Efficient Two-Step Synthesis of New 5-Substituted-1H-tetrazoles of Biological Interest

A simple procedure for the synthesis and characterization of new 3-alkoxy-3-(1H-tetrazol-5-yl)propionic acids and 2-(1H-tetrazol-5-yl)tetrahydrofuran- and -(1H-tetrazol-5-yl)-2H-pyran-3-carboxylic acids from the [2 + 3] cycloaddition reactions between the nitrile group of β-cyanocarboxylic acids with sodium azide in the presence of zinc chloride is described. The tetrazolic acids were isolated in moderate to good yields and are structurally analogous to succinic acid.