A method of modifying plant materials containing polyphenols and medical uses of materials containing polyphenols modified plants

A reducing product insulin response for use in preventing or treating diabetes, metabolic syndrome, obesity and cardiovascular diseases, wherein said product reductorde insulin response can be obtained by the method comprising the following: ) mixing at least one plant material containing polyphenols with at least one acuosopotable solvent to provide a mixture; b) heating the mixture to remove the bacterial species to provide a mezclacalentada; c) adding at least one strain of lactic acid bacteria are selected from Lactobacillus plantarum yal least one protein source chosen from the group comprising peptones, tryptones, yeast extracts and combinations thereof, in an optional order or simultaneously, the mezclacalentada to provide a fermentation mixture; d) subjecting the mixture to conditions suitable for fermentation of the fermentation mixture to provide defermentacion reducing product insulin response conditions; e) optionally removing the Lactobacillus plantarum to provide a reducing product larespuesta of free lactic acid bacteria living insulin.