New N-Substituted 7-Aminocephalosporanic Acid Derivatives as Potential Agents Against Streptococcus pneumoniae. Synthesis and in vitro Activity.
2010
The synthesis and the antimicrobial properties of a new series of cephalosporinic β-lactam antibiotics is described. The data reported in the present paper show the potential of this type of substituted cephalosporins as new anti Gram-positive antibiotic drugs. In fact, all compounds tested showed a good in vitro antibacterial activity against the most relevant Gram-positive pathogens including resistant species that currently represent unmet medical need. On the contrary, the new synthesized compounds were found to be completely devoid of any activity on Gram-negative bacteria up to a concentration of the single agent of 128 μg/ml.
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