Tumour suppressor death-associated protein kinase targets cytoplasmic HIF-1α for Th17 suppression.
2016
HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regulator PHD2.
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