Photochemical rearrangement of oxaziridines and nitrones in the hexahydroindole series: A convenient synthetic route to 1-azabicyclo[5.2.0]nonan-2-ones as novel RGD mimetics

GRAPHICS Photolysis of oxaziridines a or nitrones b provides a convenient synthetic route to fused bicyclic lactams c adequately substituted on both cycles A and B as scaffolds for mimicking conformationally constrained beta -turn peptides as in the tripeptide RGD signaling motif of fibronectin.