PDGFRB mutants found in patients with familial infantile myofibromatosis or overgrowth syndrome are oncogenic and sensitive to imatinib.

Florence A. Arts,D. Chand,Christian Pecquet,Amélie Velghe,Stefan N. Constantinescu,Bengt Hallberg,Jean-Baptiste Demoulin

PDGFRB mutants found in patients with familial infantile myofibromatosis or overgrowth syndrome are oncogenic and sensitive to imatinib.

2016

Florence A. Arts
D. Chand
Christian Pecquet
Amélie Velghe
Stefan N. Constantinescu
Bengt Hallberg
Jean-Baptiste Demoulin

Recently, germline and somatic heterozygous mutations in the platelet-derived growth factor receptor beta (PDGFRB) have been associated with familial infantile myofibromatosis (IM), which is charac ...

Keywords:

Cancer research
Germline
Myofibromatosis
PDGFRB
Infantile myofibromatosis
Growth factor receptor
Overgrowth syndrome
Mutation
Imatinib
Biology
Molecular biology
Nilotinib
imatinib mesylate
Point mutation
Tyrosine kinase

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