Cardiovascular activity of Indole derivatives by incorporating Oxadiazole, Azetidinone and Thiazolidinone Moieties: A Review

In the present review, a series of substituted Indole derivatives were studied for their cardiov ascular activity. A series of Compounds by incorporating moieties, Oxadiazole, Azetidinone, Thiazolidinone at 3 position of Indole were screened for cardiovascular activity. The Indole and Oxadiazole moiety led the compounds 2a-e, Indole and Azetidinone moiety led the compounds 3a-e, 4a-e, further Indole and Azetidinone moiety led the compounds 5a-e, for the study. The change in blood pressure (BP), heart rate (HR), effect on Carotid Occlusion (CO) and Nordaniline (NA) pressor responses were observed for th e cardiovascular profile. The cardiovascular profile of compounds 2c, 2d, 3a, 5b, 5c, 5d and 5e were suggestive of peripheral site of action.