Imidazo [1,2-a] pyridine as inhibitors of VEGF-R2.

A compound of formula (I): ** ** Formula wherein: R1 is: (a) 2-pyridonyl optionally substituted with - (CH2) 1-4NR2R3; or (b) phenyl, thienyl, thiazolyl, imidazolyl, pyrazolyl, triazolyl, oxazolyl, pyridinyl, Noxopiridinilo, or pyrimidinyl, all of which are optionally substituted with - (CH2) 0- 4NR2R3, C1-C6 alkyl optionally substituted with amino, pyrrolidinyl or morpholinyl, or 1-2 substituents independently selected from the group consisting of C1-C4 alkoxy, halogen, (C1-C6) sulfonyl, nitro, -sulfonyl (CH2) 0-4NR2R3, and -carbonyl (CH2) 0-4NR2R3; R2 is hydrogen or C1-C6 alkyl optionally substituted with hydroxy; R3 is hydrogen or C1-C6 alkyl optionally substituted with hydroxy, trifluoromethyl, or pyrrolidinyl; or R2, R3 and the nitrogen to which they are attached form piperidinyl, piperazinyl optionally substituted with C1-C6 alkyl, or morpholinyl alkyl; R4 is phenyl optionally substituted with 1-3 substituents selected from the group consisting of consisting of halogen, amino, methyl, trifluoromethyl, and nitro; R5 is C (O) NHR 6, OC (O) NHR 6, NHC (O) CH2R6, NHC (O) NHR 6 or C (S) NHR 6; n is 0-4 for OC (O) NHR 6, NHC (O) CH2R6, NHC (O) NHR 6 and n is 1-4 for C (O) NHR 6 and C (S) NHR 6; and R6 is: (a) tetrahydrobenzothiazolyl unsubstituted; or (b) phenyl, pyridinyl, pyrimidinyl, pyrazolyl, thiazolyl, isothiazolyl, thiadiazolyl, isoxazolyl, all of which are optionally substituted with 1-3 substituents independently selected from the group consisting of C1-C6 alkyl optionally substituted with hydroxy, dimethylamino, pyrrolidinyl selected, piperidinyl, or morpholinyl, C2-C6 alkenyl optionally substituted with dimethylaminocarbonyl, C1-C6 alkoxy, trifluoromethyl, difluoromethoxy, trifluoromethoxy, dimethylaminoethoxy, phenoxy, tolyl, halo, methylsulfonyl, dimethylamino, diethylamino, cyano, C3-C6 cycloalkyl optionally substituted with hydroxy, methoxy, methoxyethoxy, or methyl, 3,4- dimethylisoxazol-5-ylaminosulfonyl, tetrahydropyranyl, tetrahydropyranylaminocarbonyl, (C2- C6 alkyl) carbonyl, morpholinylcarbonyl, and piperazinylcarbonyl; or pharmaceutically acceptable salts thereof.