LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells

Marie-Laure Fogeron,Hannah Müller,Sophia Schade,Felix Dreher,Verena Lehmann,Anne Kühnel,Anne-Kathrin Scholz,Karl Kashofer,Alexandra Zerck,Beatrix Fauler,Rudi Lurz,Ralf Herwig,Kurt Zatloukal,Hans Lehrach,Johan Gobom,Eckhard Nordhoff,Bodo Lange

LGALS3BP regulates centriole biogenesis and centrosome hypertrophy in cancer cells

2013

Marie-Laure Fogeron
Hannah Müller
Sophia Schade
Felix Dreher
Verena Lehmann
Anne Kühnel
Anne-Kathrin Scholz
Karl Kashofer
Alexandra Zerck
Beatrix Fauler
Rudi Lurz
Ralf Herwig
Kurt Zatloukal
Hans Lehrach
Johan Gobom
Eckhard Nordhoff
Bodo Lange

Dysregulation of centrosome size and number is frequently associated with cancer. Fogeron et al. construct a protein-interaction network to identify proteins that are relevant for centrosome abnormalities in cancer, and show that deregulation of LGALS3BP affects centrosomal biogenesis.

Keywords:

Centrosome
Cancer cell
Cancer
Genetics
Centriole
Biogenesis
Cell biology
Biology
Centrosome cycle
Muscle hypertrophy

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