The delta F508-deletion in 99 CF patients of Switzerland

The cystic fibrosis (CF) gene has recently been isolated, and one major mutation has been defined as a 3 bp deletion in exon 10 resulting in the loss of a phenylalanine residue at position 508 (DeltaF508). The DeltaF508-deletion frequency in Europe seems to increase gradually from South-East to North-West.