PHARMACOKINETICS OF MYCOPHENOLATE MOFETIL IN HEART TRANSPLANT RECIPIENTS

Mycophenolate Mofetil (MMF) is an ester prodrug of the immunosuppressant myco-phenolic acid (MPA), which selectively inhibits the inosine monophosphate dehydrogenase (IMPDH). IMPDH converts inosine monophosphate (IMP) into xanthosine monophosphate (XMP) which will further be metabolized to ATP and GTP.