Cliniatines A–C, new Amaryllidaceae alkaloids from Clivia miniata, inhibiting Acetylcholinesterase

Cliniatines A–C (1–3), three new Amaryllidaceae alkaloids, consisting of 2,6-dimetylpyridine and lycorine-type and/or galanthamine-type were isolated from Clivia miniata (Lindl.) Bosse. The structures and absolute configurations of 1–3 were elucidated based on spectroscopic data and chemical correlation. Cliniatines A–C showed moderate inhibitory activity against acetylcholinesterase.