Variants of the IL-1 family

IL-1F5 isolated which is an antagonist of the activation / transduction serial through IL-1Rrp2, comprising the IL-1F5 an amino acid sequence having a methionine inthe position ten amino acid sequence, with the ten position relative to the N-terminal amino acid in one position the amino acid sequence, wherein the amino acid sequence seselecciona the group consisting of SEQ ID NO 7 and SEQ ID NO 9.