Formyl group activation of a bromopyrrole ester in Suzuki cross- coupling reactions: application to a formal synthesis of Polycitone A and B and Polycitrin A
2014
A new pyrrole building block is described, which allows for the regiospecific synthesis of 2,3,5trisubstituted pyrroles and 2,3,4,5-tetrasubstituted pyrroles. Optimization studies are presented for the preparation of the pyrrole building block along with the evaluation of various cross-coupling conditions and cross-coupling agents. A short, formal synthesis of the natural products Polycitone A, Polycitone B, and Polycitrin A from the pyrrole building block is also described.
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