Hypoglycemic effect of katakakhadiradi kashayam by alleviating the oxidative damage in experimentally induced diabetic rats

At present, herbal plants and their biologically active components have acquired importance in diabetes mellitus (DM) management, which has spread worldwide. The current study was carried out to analyse the antidiabetic action of  Katakakhadiradi kashayam in streptozotocin administered diabetic rats. The study was done in wistar rats by inducing diabetes using streptozotocin and nicotinamide. Diabetic rats were given katakakhadiradi kashayam with various doses of 100, 200 and 300 mg/kg/b.wt for 14 days, and its efficacy was compared with glibenclamide drug. The hypoglycemic effect of this katakakhadiradi kashayam was tested by taking blood glucose measurement in experimental rats. The oxidative damage caused by streptozotocin was analysed by LPO levels and the antioxidants status was assessed by GSH levels, GPx, SOD and CAT activities in pancreatic tissues. The antidiabetic study of katakakhadiradi kashayam showed reduction in hyperglycemia by reducing the oxidative damage in pancreatic tissue and improving the antioxidants. Overall, the reports of the study showed that katakakhadiradi kashayam could be used to improve management of diabetic rats. The acquired data suggest the hypoglycemic efficacy of katakakhadiradi kashayam, which is practically a safe herbal formulation and may be used as a good alternative to cure diabetes mellitus.