Electrochemical oxidation of the hypoglycaemic drug glipizide on carbon paste electrode and its determination in tablet dosage form

Electrochemical oxidation of glipizide was investigated at carbon paste electrode using cyclic, linear sweep, and differential pulse voltammetry (DPV). Glipizide exhibited single anodic signal in Britton-Robinson buffers in the pH range of 4.0-7.0. A very well-formed voltammetric peak of analytical meaning was obtained in Britton-Robinson buffer of pH 5.0. A method for the determination of glipizide over the concentration range in the solution 7.5 × 10 - 7 -5.0 × 10 - 5 mol L - 1 has been proposed and successfully applied to the determination of the drug in tablets. Mean recovery and relative standard deviation equalled 100.72% and 0.45%, respectively.