Cooperation of Liver Cells in the Metabolism Regulation of Bioactive Substances

Hepatocyte and nonparenchymal cells are the key foundation of liver structure and function. Hepatocyte is one of the main liver cell types, involved in large physiological processes, such as material metabolism, detoxication, and homeostasis. On the other hand, the nonparenchymal cells, including hepatic stellate cell, liver sinusoidal endothelial cell, kupffer cell, natural killer cell and pit cell, perform the material transportation, phagocytose, antigen presentation and immune tolerance. However, at present there is few research on cell cooperation between hepatocyte and the nonparenchymal cells in liver physiological and pathological process. This paper aims to comprehensively summarize the interaction between different kinds of liver cells both in health and disease conditions to provide references for further studies of the specific molecular mechanism of liver diseases.