Sensitivity to Δ9-tetrahydrocannabinol is selectively enhanced in beta-arrestin2-/- mice

Little is known about the roles of β-arrestins in the regulation of brain CB1 cannabinoid receptors. This study investigated the role of β-arrestin2 in cannabinoid behavioral effects using β-arrestin2−/− mice and their wild-type counterparts. A variety of cannabinoid ligands from different chemical