Relationships between the chemical constitution of carbamoylpiperidines and related compounds, and their inhibition of ADP-induced human blood platelet aggregation

Abstract The effect of a series of carbamoylpiperidines and related compounds on ADP-induced human blood platelet aggregation was studied. The systematic and gradual changes in the chemical structure of these synthetic entities disclosed highly significant relationships between molecular constitution, physicochemical properties and biodynamic effects, and yielded data suggesting -for the first time- platelet membrane inhibitory target sites spaced at 8 A. Inhibitory potencies culminated with a compound active at 5 μM concentrations; the latter and a number of other derivatives were much more effective than aspirin.