Organocatalytic Cascade Reactions to Multi-functionalized Chiral Cyclic Ethers through Vinylidene ortho-Quinone Methides

2021 
An organocatalytic approach to installing various alcohols into the carbonyl of α,β-unsaturated ketones mediated by VQM intermediates was achieved, followed by the dearomatization to provide the stereo-defined cyclic ethers via a cascade process. Along with transformations, this strategy affords efficient access to the underexplored chiral cyclic ether chemospace.
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