NS-3 (CG3703), an analog of thyrotropin-releasing hormone, ameliorates cognitive impairment in rats
1995
Abstract The effects of thyrotropin-releasing hormone (TRH) and its analog, N-[[(3R, 6R)-6-methyl-5-oxo-thiomorpholinyl] carbonyl]- l -histidyl- l -prolinamide tetrahydrate (NS-3, CG3703) on disturbance of memory of a passive avoidance response (PAR) and an escape response in rats were investigated. NS-3 improved amnesia caused by scopolamine, electroconvulsive shock (ECS), and cycloheximide (CXM), but TRH improved only the ECS-induced amnesia. NS-3 reversed learning deficits caused by hypercapnia, but TRH had no effect. These differences in the effect between NS-3 and TRH may be due to their biological half-life in rat plasma. These results suggest that NS-3 possesses more potent antiamnestic effects than TRH in rats.
Keywords:
- Correction
- Source
- Cite
- Save
- Machine Reading By IdeaReader
46
References
8
Citations
NaN
KQI