IRAK-4 inhibitors. Part 1: a series of amides.

George Martin Buckley,Lewis Gowers,Alicia P. Higueruelo,Kerry Jenkins,Stephen Robert Mack,Trevor Morgan,David M. Parry,William R. Pitt,Oliver Rausch,Marianna Dilani Richard,Verity Margaret Sabin,Joanne L. Fraser

IRAK-4 inhibitors. Part 1: a series of amides.

2008

George Martin Buckley
Lewis Gowers
Alicia P. Higueruelo
Kerry Jenkins
Stephen Robert Mack
Trevor Morgan
David M. Parry
William R. Pitt
Oliver Rausch
Marianna Dilani Richard
Verity Margaret Sabin
Joanne L. Fraser

Abstract The synthesis and profile of a series of amides are described. Some of these compounds were potent IRAK-4 inhibitors and two examples were evaluated in vivo.

Keywords:

Non-specific serine/threonine protein kinase
Enzyme
Biochemistry
Amide
Organic chemistry
Chemistry
Molecular model
In vivo
Docking (dog)
Chemical synthesis
Stereochemistry

Correction
Source
Cite
Save
Machine Reading By IdeaReader

References

Citations