An easy route to synthesis of thiophene tagged pyrimidin 2-thiones as antibacterial agents

A series of substituted pyrimidin-2-thiones tagged with thiophene moiety was synthesized by an easy pr ocedure. The reaction of chalcones 1-5 and thiourea 6 in the presence potassium hydroxide in ethanol yielded 6-aryl -4-(thiophen-2-yl) -5,6-dihydropyrimidin-2(1H) -ones, 7-11 in good yields. The synthesized new compounds were characterized by 1H NMR, 13C NMR, Mass spectral studies and elemental analysis and were screened for their antifungal susceptibility against different bacteria species.