Effect of new pesticide on DNA damage in different mice cells

Objective To study the effects of a new pesticide on DNA damage of erythroblast cells and seminal cells in mice in vitro.Methods The comet assay was used to detect the DNA damage induced by a new pesticide compound at the different dose.Results Compared with the control group,the DNA migration rate were increase significantly at (10?g/L)test doses to erythroblast cells(P0.05).DNA migration of seminal cells(at test dose of 10,100,500 !mg/L)exhibited significant dose-effect relationship.The DNA damage in seminal cell was more sensitive than that of erythroblast cell.Conclusion The new pesticide could cause DNA damage of mice cells in vitro.