Role of prostanoid EP3/1 receptors in mechanisms of emesis and defaecation in ferrets

Abstract Prostanoid EP receptor agonists are used for a number of clinical indications but may be associated with gastric disturbance. In the present studies we used the ferret and sulprostone (30 µg/kg, i.p.) to investigate the role of EP 3/1 receptors in mechanisms of emesis and defaecation. The emetic response was antagonized significantly by (+)-(2  S ,3  S )−3-(2-methoxybenzylamino)−2-phenlypiperidine hydrochloride (CP-99,994; 10 mg/kg, i.p.; P