Adaptive-regulation of pancreatic acinar mitochondrial thiamin pyrophosphate uptake process: Possible involvement of epigenetic mechanism(s)

Our findings show, for the first time, that the mitochondrial thiamin pyrophosphate (MTPP) uptake process is adaptively regulated by the prevailing thiamin level in pancreatic acinar cells and this regulation is mediated, at least in part, by transcriptional and epigenetic mechanism(s) affecting the SLC25A19 promoter.