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Neil Q. McDonald

Birkbeck, University of London
London Research Institute
Francis Crick Institute

180

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13195

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Co-ordinated control of the Aurora B abscission checkpoint by PKCε complex assembly, midbody recruitment and retention.

2021 Biochemical Journal
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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

2021 Structure
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A genetically-encoded crosslinker screen identifies SERBP1 as a PKCε substrate influencing translation and cell division.

2021 Nature Communications
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Activated neutrophil fluorescent imaging technique for human lungs.

2021 Scientific Reports
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Cryo-EM structures of the XPF-ERCC1 endonuclease reveal how DNA-junction engagement disrupts an auto-inhibited conformation

2020 Nature Communications
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Equivocal, explicit and emergent actions of PKC isoforms in cancer.

2020 Nature Reviews Cancer
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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

2020 bioRxiv
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Correction to Insights into Current Tropomyosin Receptor Kinase (TRK) Inhibitors: Development and Clinical Application.

2020 Journal of Medicinal Chemistry
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Bioisosteric discovery of NPA101.3, a second generation RET/VEGFR2 inhibitor optimized for single-agent polypharmacology.

2020 Journal of Medicinal Chemistry
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XPF-ERCC1 Cryo-EM Structure, Apo-form

2020
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