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Elena Friedmann

École Polytechnique Fédérale de Lausanne

4

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A γ-secretase-like intramembrane cleavage of TNFα by the GxGD aspartyl protease SPPL2b

2006 Nature Cell Biology
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SPPL2a and SPPL2b promote intramembrane proteolysis of TNFα in activated dendritic cells to trigger IL-12 production

2006 Nature Cell Biology
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Consensus Analysis of Signal Peptide Peptidase and Homologous Human Aspartic Proteases Reveals Opposite Topology of Catalytic Domains Compared with Presenilins

2004 Journal of Biological Chemistry
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Targeting Presenilin-type Aspartic Protease Signal Peptide Peptidase with γ-Secretase Inhibitors

2003 Journal of Biological Chemistry
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