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Bruce E. Tomczuk

Johnson & Johnson Pharmaceutical Research and Development

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Optimization of a Potent Class of Arylamide Colony-Stimulating Factor-1 Receptor Inhibitors Leading to Anti-inflammatory Clinical Candidate 4-Cyano-N-[2-(1-cyclohexen-1-yl)-4-[1-[(dimethylamino)acetyl]-4-piperidinyl]phenyl]-1H-imidazole-2-carboxamide (JNJ-28312141).

2011 Journal of Medicinal Chemistry
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Structure-Activity and Crystallographic Analysis of a New Class of Non-amide-based Thrombin Inhibitor.

2010 ChemInform
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Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.

2010 Journal of Medicinal Chemistry
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Reducing ion channel activity in a series of 4-heterocyclic arylamide FMS inhibitors

2010 Bioorganic & Medicinal Chemistry Letters
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JNJ-28312141, a novel orally active colony-stimulating factor-1 receptor/FMS-related receptor tyrosine kinase-3 receptor tyrosine kinase inhibitor with potential utility in solid tumors, bone metastases, and acute myeloid leukemia

2009 Molecular Cancer Therapeutics
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Synthesis and evaluation of novel 3,4,6-substituted 2-quinolones as FMS kinase inhibitors

2008 Bioorganic & Medicinal Chemistry Letters
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Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s

2008 Bioorganic & Medicinal Chemistry Letters
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Pharmacokinetics of TDP223206 following intravenous and oral administration to intact rats and intravenous administration to bile duct‐cannulated rats

2008 Biopharmaceutics & Drug Disposition
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Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.

2008 Bioorganic & Medicinal Chemistry Letters
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Orally efficacious thrombin inhibitors with cyanofluorophenylacetamide as the P2 motif

2008 Bioorganic & Medicinal Chemistry Letters
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