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Jacob I. Contreras

University of Nebraska Medical Center

13

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352

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Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy.

2021 European Journal of Medicinal Chemistry
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Symbiotic Prodrugs (SymProDs) Dual Targeting of NFkappaB and CDK.

2020 Chemical Biology & Drug Design
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Correction: Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

2020 Oncotarget
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CDK5 Inhibitor Downregulates Mcl-1 and Sensitizes Pancreatic Cancer Cell Lines to Navitoclax

2019 Molecular Pharmacology
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Chemical Genetic Screens Identify Kinase Inhibitor Combinations that Target Anti-Apoptotic Proteins for Cancer Therapy

2018 ACS Chemical Biology
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Recent advances in cancer drug development: Targeting induced myeloid cell leukemia-1 (mcl-1) differentiation protein

2018 Current Medicinal Chemistry
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Citations (11)
Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy

2018 Oncotarget
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Chemically induced degradation of CDK9 by a proteolysis targeting chimera (PROTAC)

2017 Chemical Communications
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Development of 1-((1,4-trans)-4-Aryloxycyclohexyl)-3-arylurea Activators of Heme-Regulated Inhibitor as Selective Activators of the Eukaryotic Initiation Factor 2 Alpha (eIF2α) Phosphorylation Arm of the Integrated Endoplasmic Reticulum Stress Response

2017 Journal of Medicinal Chemistry
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Discovery and characterization of small molecule Rac1 inhibitors

2017 Oncotarget
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Citations (15)