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Lawrence R. Dick

Millennium Pharmaceuticals

24

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3726

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The proteasome as a target for protozoan parasites

2019 Expert Opinion on Therapeutic Targets
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Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor

2017 Nature Chemical Biology
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Absolute Quantification of E1, Ubiquitin-Like Proteins and Nedd8–MLN4924 Adduct by Mass Spectrometry

2013 Cell Biochemistry and Biophysics
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Quantifiable analysis of cellular pathway inhibition of a Nedd8-activating enzyme inhibitor, MLN4924, using AlphaScreen.

2013 Analytical Biochemistry
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Treatment-Emergent Mutations in NAEβ Confer Resistance to the NEDD8-Activating Enzyme Inhibitor MLN4924

2012 Cancer Cell
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Mechanistic Studies on Activation of Ubiquitin and Di-ubiquitin-like Protein, FAT10, by Ubiquitin-like Modifier Activating Enzyme 6, Uba6

2012 Journal of Biological Chemistry
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Changes in the ratio of free NEDD8 to ubiquitin triggers NEDDylation by ubiquitin enzymes

2012 Biochemical Journal
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Optimization of a series of dipeptides with a P3 β-neopentyl asparagine residue as non-covalent inhibitors of the chymotrypsin-like activity of human 20S proteasome

2012 MedChemComm
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Mechanistic Studies of Substrate-assisted Inhibition of Ubiquitin-activating Enzyme by Adenosine Sulfamate Analogues

2011 Journal of Biological Chemistry
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Ubiquitin-like protein conjugation and the ubiquitin–proteasome system as drug targets

2011 Nature Reviews Drug Discovery
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Citations (392)