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Vivek K. Unni

Oregon Health & Science University

24

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Effects of Alpha-Synuclein Targeted Antisense Oligonucleotides on Lewy Body-Like Pathology and Behavioral Disturbances Induced by Injections of Pre-Formed Fibrils in the Mouse Motor Cortex.

2021 Journal of Parkinson's disease
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Genetic deletion of Polo-like kinase 2 reduces alpha-synuclein serine-129 phosphorylation in presynaptic terminals but not Lewy bodies.

2021 Journal of Biological Chemistry
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In vivo aggregation of presynaptic alpha-synuclein is not influenced by its phosphorylation at serine-129.

2021 Neurobiology of Disease
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Antisense oligonucleotides targeting alpha-synuclein reduce pre-formed fibril-induced Lewy pathology and improve some domains of cognitive and motor performance

2020 bioRxiv
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Trans-synaptic and retrograde axonal spread of Lewy pathology following pre-formed fibril injection in an in vivo A53T alpha-synuclein mouse model of synucleinopathy

2020 Acta neuropathologica communications
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Multicolor lineage tracing using in vivo time-lapse imaging reveals coordinated death of clonally related cells in the developing vertebrate brain

2019 Developmental Biology
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Utilizing Correlated Light and Electron Microscopy to Examine Alpha-Synuclein Pathology in a Mouse Model of Parkinson's Disease

2019 Microscopy and Microanalysis
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Alpha-synuclein is a DNA binding protein that modulates DNA repair with implications for Lewy body disorders

2019 Scientific Reports
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G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons

2016 The Journal of Neuroscience
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Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export

2015 Nature Genetics
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Citations (170)