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Christine E. Brotherton-Pleiss

Hoffmann-La Roche

10

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141

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Abstract 1230: High-affinity azetidine-based small-molecules as a new class of direct inhibitors of STAT3 activity and breast cancer phenotype

2021
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A potent seven-membered cyclic BTK (Bruton's tyrosine Kinase) chiral inhibitor conceived by structure-based drug design to lock its bioactive conformation.

2019 Bioorganic & Medicinal Chemistry Letters
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Abstract 4792: Azetidine functionalized small-molecules potently inhibit STAT3 signaling and block tumor growth in human breast cancer xenografts

2019 Cancer Research
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Discovery of a Potent (4R,5S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling

2018 Journal of Medicinal Chemistry
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Composés de sulfonamide substitués

2013
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Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist

2010 Bioorganic & Medicinal Chemistry Letters
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Discovery of piperidin-4-yl-aminopyrimidines as HIV-1 reverse transcriptase inhibitors. N-benzyl derivatives with broad potency against resistant mutant viruses.

2010 Bioorganic & Medicinal Chemistry Letters
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Spiropiperidine CCR5 antagonists.

2009 Bioorganic & Medicinal Chemistry Letters
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Derivatives of 2- (piperidin-4-yl) -4-phenoxy-phenylamino-pyrimidine or as non-nucleoside inhibitors of reverse transcriptase

2007
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Structure-based design of six novel classes of nonpeptide antagonists of the bradykinin B2 receptor

2000 Bioorganic & Medicinal Chemistry Letters
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Citations (10)