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Fang Tian
Fang Tian
Merck & Co.
Chemistry
Biochemistry
atp competitive
Organic chemistry
Combinatorial chemistry
4
Papers
87
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Discovery of a novel series of potent MK2 non-ATP competitive inhibitors using 1,2-substituted azoles as cis-amide isosteres.
2014
Bioorganic & Medicinal Chemistry Letters
Dong Xiao
Xiaohong Zhu
Michael Sofolarides
Sylvia Degrado
Ning Shao
Ashwin U. Rao
Xiao Chen
Robert Aslanian
James Fossetta
Fang Tian
Prashant Trivedi
Daniel Lundell
Anandan Palani
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Citations (10)
Conformation constraint of anilides enabling the discovery of tricyclic lactams as potent MK2 non-ATP competitive inhibitors.
2013
Bioorganic & Medicinal Chemistry Letters
Dong Xiao
Anandan Palani
Xianhai Huang
Michael Sofolarides
Wei Zhou
Xiao Chen
Robert Aslanian
Zhuyan Guo
James Fossetta
Fang Tian
Prashant Trivedi
Peter Spacciapoli
Charles Whitehurst
Daniel Lundell
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Citations (18)
Facile synthesis of tetracyclic azepine and oxazocine derivatives and their potential as MAPKAP-K2 (MK2) inhibitors.
2012
Bioorganic & Medicinal Chemistry Letters
Ashwin U. Rao
Dong Xiao
Xianhai Huang
Wei Zhou
James Fossetta
Dan Lundell
Fang Tian
Prashant Trivedi
Robert Aslanian
Anandan Palani
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Citations (39)
A three-step protocol for lead optimization: Quick identification of key conformational features and functional groups in the SAR studies of non-ATP competitive MK2 (MAPKAPK2) inhibitors
2012
Bioorganic & Medicinal Chemistry Letters
Xianhai Huang
Xiaohong Zhu
Xiao Chen
Wei Zhou
Dong Xiao
Sylvia Degrado
Robert Aslanian
James Fossetta
Daniel Lundell
Fang Tian
Prashant Trivedi
Anandan Palani
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Citations (20)
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