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José Angel Fernández-Higuero

University of the Basque Country

18

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153

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MLb-LDLr: A Machine Learning Model for Predicting the Pathogenicity of LDLr Missense Variants

2021 JACC: Basic to Translational Science
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All-or-none amyloid disassembly via chaperone-triggered fibril unzipping favors clearance of α-synuclein toxic species.

2021 Proceedings of the National Academy of Sciences of the United States of America
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Truncation-Driven Lateral Association of α-Synuclein Hinders Amyloid Clearance by the Hsp70-based Disaggregase

2021 International Journal of Molecular Sciences
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Extraction and refolding determinants of chaperone-driven aggregated protein reactivation

2020 Journal of Molecular Biology
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Regulation of Human Hsc70 ATPase and Chaperone Activities by Apg2: Role of the Acidic Subdomain

2019 Journal of Molecular Biology
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Structural and functional insights on the roles of molecular chaperones in the mistargeting and aggregation phenotypes associated with primary hyperoxaluria type I

2019 Advances in Protein Chemistry
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Activation of the DnaK-ClpB Complex is Regulated by the Properties of the Bound Substrate

2018 Scientific Reports
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Crowding Modulates the Conformation, Affinity, and Activity of the Components of the Bacterial Disaggregase Machinery

2016 Journal of Molecular Biology
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Structural analysis of APOB variants, p.(Arg3527Gln), p.(Arg1164Thr) and p.(Gln4494del), causing Familial Hypercholesterolaemia provides novel insights into variant pathogenicity

2016 Scientific Reports
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Structural changes induced by acidic pH in human apolipoprotein B-100

2016 Atherosclerosis
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