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Stig Hansen

Sunesis Pharmaceuticals

17

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655

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Utilizing structure based drug design and metabolic soft spot identification to optimize the in vitro potency and in vivo pharmacokinetic properties leading to the discovery of novel reversible Bruton's tyrosine kinase inhibitors.

2021 Bioorganic & Medicinal Chemistry
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Optimization of novel reversible Bruton’s tyrosine kinase inhibitors identified using Tethering-fragment-based screens

2019 Bioorganic & Medicinal Chemistry
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Abstract C198: PDK1 inhibitors SNS-229 and SNS-510 cause pathway modulation, apoptosis and tumor regression in hematologic cancer models in addition to solid tumors

2015 Molecular Cancer Therapeutics
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Abstract C186: SNS-062 is a potent noncovalent BTK inhibitor with comparable activity against wild type BTK and BTK with an acquired resistance mutation

2015 Molecular Cancer Therapeutics
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Antitumor activity and suppression of AKT pathway activation by PDK1 inhibitor SNS-391.

2014 Journal of Clinical Oncology
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Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.

2011 Bioorganic & Medicinal Chemistry Letters
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SNS-314, a pan-Aurora kinase inhibitor, shows potent anti-tumor activity and dosing flexibility in vivo

2010 Cancer Chemotherapy and Pharmacology
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Crystal structure of the mouse Aurora-A catalytic domain (Asn186->Gly, Lys240->Arg, Met302->Leu) in complex with Compound 290.

2009
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Capture Methods for Fragment‐Based Discovery

2008
- Stig Hansen
- Daniel A. Erlanson
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Mouse Aurora A: Expression in Escherichia coli and purification

2007 Protein Expression and Purification
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Citations (7)