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Christine C. Lee
Christine C. Lee
Rensselaer Polytechnic Institute
Molecular biology
Biology
Amyloid
Complementarity determining region
Antibody
5
Papers
194
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Design and Optimization of Anti-Amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide
2016
Journal of Biological Chemistry
Christine C. Lee
Mark C. Julian
Kathryn E. Tiller
Fanling Meng
Sarah E. DuConge
Rehana Akter
Daniel P. Raleigh
Peter M. Tessier
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Citations (32)
Intrahippocampal administration of a domain antibody that binds aggregated amyloid-β reverses cognitive deficits produced by diet-induced obesity.
2016
Biochimica et Biophysica Acta
Danielle M. Osborne
Dennis P. Fitzgerald
Kelsey E. O'Leary
Brian M. Anderson
Christine C. Lee
Peter M. Tessier
Ewan C. McNay
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Citations (9)
Co-evolution of affinity and stability of grafted amyloid-motif domain antibodies
2015
Protein Engineering Design & Selection
Mark C. Julian
Christine C. Lee
Kathryn E. Tiller
Lilia A. Rabia
Evan K. Day
Arthur J. Schick
Peter M. Tessier
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Citations (25)
Optimal charged mutations in the complementarity-determining regions that prevent domain antibody aggregation are dependent on the antibody scaffold
2014
Protein Engineering Design & Selection
Joseph M. Perchiacca
Christine C. Lee
Peter M. Tessier
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Citations (56)
Toward aggregation-resistant antibodies by design
2013
Trends in Biotechnology
Christine C. Lee
Joseph M. Perchiacca
Peter M. Tessier
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Citations (72)
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