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Erik De Clercq

Rega Institute for Medical Research
Katholieke Universiteit Leuven

2017

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81057

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Design, synthesis, and mechanistic investigations of phenylalanine derivatives containing a benzothiazole moiety as HIV-1 capsid inhibitors with improved metabolic stability.

2022 European Journal of Medicinal Chemistry
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Synthesis, characterization and biological evaluation of 1,3-thiazolidine-4-ones derived from (2S)-2-benzoylamino-3-methylbutanohydrazide hydrazones

2021
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Design, synthesis, and antiviral evaluation of novel piperidine-substituted arylpyrimidines as HIV-1 NNRTIs by exploring the hydrophobic channel of NNIBP.

2021 Bioorganic Chemistry
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Medicinal chemistry strategies for discovering antivirals effective against drug-resistant viruses.

2021 Chemical Society Reviews
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Exploiting the hydrophobic channel of the NNIBP: Discovery of novel diarylpyrimidines as HIV-1 NNRTIs against wild-type and K103N mutant viruses.

2021 Bioorganic & Medicinal Chemistry
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1984-Discovery of the First Anti-HIV Drug, Suramin.

2021 Viruses
- Erik De Clercq
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Design, synthesis and anti-HIV evaluation of novel 5-substituted diarylpyrimidine derivatives as potent HIV-1 NNRTIs.

2021 Bioorganic & Medicinal Chemistry
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Chapter 1. Overview of Antiviral Drug Discovery and Development: Viral Versus Host Targets

2021
- Guangdi Li
- Erik De Clercq
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Chemical Space Exploration of Novel Naphthyl-carboxamide-diarylpyrimidine derivatives with Potent anti-HIV-1 Activity

2021 Bioorganic Chemistry
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Design, synthesis, and mechanism study of dimerized phenylalanine derivatives as novel HIV-1 capsid inhibitors.

2021 European Journal of Medicinal Chemistry
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